LEREG was created in the 1990s by Prof. Paulo Arruda (Institute of Biology/Unicamp) in the same year that CBMEG was founded. LEREG's research focus is the regulation of gene expression. Since its creation, LEREG has been involved in large collaborative projects with national and international institutions, which led to the coordination of important projects of international projection, such as the sequencing of Xyllela fastidiosa (1997) and sugarcane (2002), which represented milestones in Brazilian science.

In 2015, LEREG brought to CBMEG the agreement with the international structural genomics consortium (SGC - Structural Genomics Consortium) that resulted in the creation of CQMED (Center for Medicinal Chemistry). In 2018, LEREG became host to the GCCRC (Center for Genomics Applied to Climate Change), a Fapesp Engineering Research Center resulted from the partnership Embrapa and Unicamp. Its mission is the creation of biotechnological assets through genomics applied to the adaptation of crops to stresses associated with climate change.