Centro de Biologia Molecular e Engenharia Genética da Unicamp
SELECTED PUBLICATIONSThe main studies published by our laboratories

Use the tabs on the side to access the main publications
of each one of our laboratories.

  • Cardoso-Silva CB, Aono AH, Mancini MC, Sforça DA, da Silva CC, Pinto LR, Adams KL and de Souza AP (2022) Taxonomically Restricted Genes Are Associated With Responses to Biotic and Abiotic Stresses in Sugarcane (Saccharum spp.). Front. Plant Sci. 13:923069. https://doi.org/10.3389/fpls.2022.923069
  • Rosolen RR, Aono AH, Almeida DA, Ferreira Filho JA, Horta MAC and De Souza AP (2022) Network Analysis Reveals Different Cellulose Degradation Strategies Across Trichoderma harzianum Strains Associated With XYR1 and CRE1. Front. Genet. 13:807243. https://doi.org/10.3389/fgene.2022.807243
  • Aono AH, Ferreira RC, Moraes Ada, Lara LA, Pimenta RJ, Costa EA, Pinto LR, Landell MG, Santos MF, Jank L, Barrios SC, do Valle CB, Chiari L, Garcia AA, Kuroshu RM, Lorena AC, Gorjanc G, and de Souza AP (2022) A joint learning approach for genomic prediction in polyploid grasses. Sci Rep 12, 12499. https://doi.org/10.1038/s41598-022-16417-7
  • Pimenta RJP, Aono AH, Villavicencio Burbano RC, Coutinho AE, da Silva CC, dos Anjos IA, Perecin D, Landell MGA, Gonçalves MC, Pinto LR, and de Souza, AP. (2021) Genome-wide approaches for the identification of markers and genes associated with sugarcane yellow leaf virus resistance.  Sci Rep 11, 15730. https://doi.org/10.1038/s41598-021-95116-1
  • Francisco FR, Aono AH, da Silva CC, Gonçalves PS, Scaloppi Junior EJ, Le Guen V, Fritsche-Neto R, Souza LM and Souza AP (2021) Unravelling Rubber Tree Growth by Integrating GWAS and Biological Network-Based Approaches. Front. Plant Sci. 12:768589. https://doi.org/10.3389/fpls.2021.768589
  • Ferreira RCU, Moraes ACL, Chiari L, Simeão RM, Vigna BCZ and de Souza AP (2021) An Overview of the Genetics and Genomics of the Urochloa Species Most Commonly Used in Pastures. Front. Plant Sci. 12:770461. https://doi.org/10.3389/fpls.2021.770461
  • Santos CA, Morais MAB, Terrett OM, Lyczakowski JJ, Zanphorlin LM, Ferreira-Filho JA, Tonoli CCC, Murakami MT, Dupree P, and Souza AP (2019) An engineered GH1 β-glucosidase displays enhanced glucose tolerance and increased sugar release from lignocellulosic materials. Sci Rep 9, 4903. https://doi.org/10.1038/s41598-019-41300-3
  • Cruz MV, Mori GM, Signori-Müller C, da Silva CC, Oh DH, Dassanayake M, Zucchi MI, Oliveira RS, and de Souza AP (2019) Local adaptation of a dominant coastal tree to freshwater availability and solar radiation suggested by genomic and ecophysiological approaches. Sci Rep 9, 19936. https://doi.org/10.1038/s41598-019-56469-w
  • Horta MAC, Filho JAF, Murad NF, de Oliveira Santos E, dos Santos CA, Mendes JS, Brandão MM, Azzoni SF and de Souza AP (2018). Network of proteins, enzymes and genes linked to biomass degradation shared by Trichoderma species. Sci Rep, 8(1). https://doi.org/10.1038/s41598-018-19671-w
  • Alves FM, Sartori NLB, Zucchi MI, Azevedo-Tozzi AMG, Tambarussi EV, Alves-Pereira A and de Souza AP (2018). Genetic structure of two Prosopis species in Chaco areas: A lack of allelic diversity diagnosis and insights into the allelic conservation of the affected species. Ecology and Evolution, 8(13), 6558–6574. https://doi.org/10.1002/ece3.4137

Em breve.

Ciamponi, F.E., Procópio, D.P., Murad, N.F., Franco, T.T., Basso, T.O., Brandão, M.M. Multi-omics network model reveals key genes associated with p-coumaric acid stress response in an industrial yeast strain. (2022) Scientific Reports, 12 (1), art. no. 22466. DOI: 10.1038/s41598-022-26843-2. OPEN ACCESS: All Open Access, Gold, Green

Béliveau, C., Gagné, P., Picq, S., Vernygora, O., Keeling, C.I., Pinkney, K., Doucet, D., Wen, F., Johnston, J.S., Maaroufi, H., Boyle, B., Laroche, J., Dewar, K., Juretic, N., Blackburn, G., Nisole, A., Brunet, B., Brandão, M., Lumley, L., Duan, J., Quan, G., Lucarotti, C.J., Roe, A.D., Sperling, F.A.H., Levesque, R.C., Cusson, M. The Spruce Budworm Genome: Reconstructing the Evolutionary History of Antifreeze Proteins. (2022) Genome Biology and Evolution, 14 (6), art. no. evac087. DOI: 10.1093/gbe/evac087.  OPEN ACCESS: All Open Access, Gold, Green

Murad, N.F., Silva-Brandão, K.L., Brandão, M.M. Mechanisms behind polyphagia in a pest insect: Responses of Spodoptera frugiperda (J.E. Smith) strains to preferential and alternative larval host plants assessed with gene regulatory networks. (2021) Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1864 (3), art. no. 194687. DOI: 10.1016/j.bbagrm.2021.194687. 

Murad, N.F., Brandão, M.M. Probabilistic Graphical Models Applied to Biological Networks. (2021) Advances in Experimental Medicine and Biology, 1346, pp. 119-130. DOI: 10.1007/978-3-030-80352-0_7. 

de Barros Dantas, L.L., Brandão, M.M. Interactomes: Experimental and In Silico Approaches. (2021) Advances in Experimental Medicine and Biology, 1346, pp. 107-117. DOI: 10.1007/978-3-030-80352-0_6.

Silva-Brandão, K.L., Murad, N.F., Peruchi, A., Martins, C.H.Z., Omoto, C., Figueira, A., Brandão, M.M., Trigo, J.R. Transcriptome differential co-expression reveals distinct molecular response of fall-armyworm strains to DIMBOA. (2021) Pest Management Science, 77 (1), pp. 518-526. DOI: 10.1002/ps.6051

Brandão, M.M., Dantas, L.L., Silva-Filho, M.C. AtPIN: Arabidopsis thaliana protein interaction network. (2009) BMC Bioinformatics, 10, art. no. 454. DOI: 10.1186/1471-2105-10-454. OPEN ACCESS: All Open Access, Gold, Green

  • Fanti, R. C., Vasconcelos, S. N. S., Catta-Preta, C. M. C., Sullivan, J. R., Riboldi, G. P., dos Reis, C. v., Ramos, P. Z., Edwards, A. M., Behr, M. A., & Couñago, R. M. (2022). A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.2c00073
  • Lins, É. M., Oliveira, N. C. M., Reis, O., Ferrasa, A., Herai, R., Muotri, A. R., Massirer, K. B., & Bengtson, M. H. (2022). Genome-wide translation control analysis of developing human neurons. Molecular Brain, 15(1), 55. https://doi.org/10.1186/s13041-022-00940-9
  • Wu, Qin, David Y. Nie, Wail Ba-alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, et al. 2022. “PRMT Inhibition Induces a Viral Mimicry Response in Triple-Negative Breast Cancer.” Nature Chemical Biology, May. https://doi.org/10.1038/s41589-022-01024-4.
  • Segretti, Natanael D., Jéssica E. Takarada, Marcos A. Ferreira, André da Silva Santiago, Bruno V.M. Teodoro, Mariana C.F.C.B. Damião, Paulo H. Godoi, et al. 2022. “Discovery of Novel Benzothiophene Derivatives as Potent and Narrow Spectrum Inhibitors of DYRK1A and DYRK1B.” Bioorganic & Medicinal Chemistry Letters 68 (July): 128764. https://doi.org/10.1016/j.bmcl.2022.128764.
  • Papes, Fabio, Antonio P. Camargo, Janaina S. de Souza, Vinicius M. A. Carvalho, Ryan A. Szeto, Erin LaMontagne, José R. Teixeira, et al. 2022. “Transcription Factor 4 Loss-of-Function Is Associated with Deficits in Progenitor Proliferation and Cortical Neuron Content.” Nature Communications 13 (1): 2387. https://doi.org/10.1038/s41467-022-29942-w.
  • Ricardo, Ricardo A., André da Silva Santiago, Martin P. Schwalm, Zexi Hu, Caio v. dos Reis, Jessica E. Takarada, Priscila Mezzomo, et al. 2022. “Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.” Journal of Medicinal Chemistry 65 (4). https://doi.org/10.1021/acs.jmedchem.1c01165.
  • Scott, Fiona, Angela M. Fala, Jessica E. Takarada, Mihaela P. Ficu, Lewis E. Pennicott, Tristan D. Reuillon, Rafael M. Couñago, Katlin B. Massirer, Jonathan M. Elkins, and Simon E. Ward. 2022. “Development of Dihydropyrrolopyridinone-Based PKN2/PRK2 Chemical Tools to Enable Drug Discovery.” Bioorganic and Medicinal Chemistry Letters 60.  https://doi.org/10.1016/j.bmcl.2022.128588.
  • Eduful, Benjamin J., Sean N. O’Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph R. Pilotte, et al. 2021. “Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.” Journal of Medicinal Chemistry 64 (15): 10849–77. https://doi.org/10.1021/acs.jmedchem.0c02274.
  • Ferreira, Tiago R., Rafael M. Couñago, and Nilmar S. Moretti. 2021. “Raising the Bar(-Seq) in Leishmania Genetic Screens.” Trends in Parasitology 37 (5): 367–69. https://doi.org/10.1016/j.pt.2021.03.002.
  • Cabarca, Sindy, Maximilia Frazão de Souza, Andrew Albert de Oliveira, Gabriel S. Vignoli Muniz, M. Teresa Lamy, Caio Vinicius dos Reis, Jessica Takarada, et al. 2021. “Structure of the Mycobacterium Tuberculosis CPknF and Conformational Changes Induced in Forkhead-Associated Regulatory Domains.” Current Research in Structural Biology 3: 165–78. https://doi.org/10.1016/j.crstbi.2021.07.001.

DA CRUZ PRS, ANANINA G, SECOLIN R, DA-SILVA-LOPES VL, LIMA CSP, DE FRANÇA PHC, DONATTI A, LOURENÇO GJ, DE ARAUJO TK, SIMIONI M, LOPES-CENDES I, COSTA FF, DE MELO MB. Demographic history differences between Hispanics and Brazilians imprint haplotype features. G3 (Bethesda). 2022 Jul 6;12(7):jkac111. doi: 10.1093/g3journal/jkac111. 

VITURINO MG, NETO JM, BAJANO FF, COSTA SM, ROQUE AB, BORGES GF, ANANINA G, RIM PH, MEDINA FM, COSTA FF, VASCONCELLOS JP, MELO MB. Evaluation of APOE polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian population. Exp Biol Med (Maywood). 2021 May;246(10):1148-1155. doi: 10.1177/1535370220985466.

ITO MT, DA SILVA COSTA SM, BAPTISTA LC, CARVALHO-SIQUEIRA GQ, ALBUQUERQUE DM, RIOS VM, OSPINA-PRIETO S, SAEZ R, VIEIRA KP, CENDES F, OZELO MC, SAAD STO, COSTA FF, MELO MB. Angiogenesis-related genes in endothelial progenitor cells may be involved in sickle cell stroke. J Am Heart Assoc. 2020;9(3):e014143. doi: 10.1161/JAHA.119.014143. 

BAPTISTA LC, COSTA ML, SURITA FG, ROCHA CS, LOPES-CENDES I, SOUZA BB, COSTA FF, MELO MB. Placental transcriptome profile of women with sickle cell disease reveals differentially expressed genes involved in migration, trophoblast differentiation and inflammation. Blood Cells Mol Dis. 2020 Sep;84:102458. doi: 10.1016/j.bcmd.2020.102458. 

HAUSER MA, ALLINGHAM, RR, AUNG T, VAN DER HEIDE CJ, ROTTER JI, WANG SH, ... MELO MB, ... KHOR CC.APBB2 is a significant risk locus for primary open angle glaucoma in individuals of African ancestry. JAMA. 2019;322(17):1682-1691. doi: 10.1001/jama.2019.16161.

CRUZ PRS, ANANINA G, GIL-DA-SILVA-LOPES VS, SIMIONI M, MENAA F, BEZERRA MAC, DOMINGOS IF, ARAÚJO AS, PELLEGRINO R, HAKONARSON H, COSTA FF, MELO MB. Genetic comparison of sickle cell anaemia cohorts from Brazil and United States reveals high levels of divergence. Sci Rep. 2019;9(1):10896. doi: 10.1038/s41598-019-47313-2. 

CARVALHO-SIQUEIRA GQ, ANANINA G, SOUZA BB, BORGES MG, ITO MT, SILVA-COSTA SM, DOMINGOS IF, FALCÃO DA, LOPES-CENDES I, BEZERRA MAC, ARAÚJO AS, LUCENA-ARAÚJO AR, GONÇALVES MS, SAAD STO, COSTA FF, MELO MB. Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients. Exp Biol Med. (Maywood) 2019; 244(11):932-39. doi: 10.1177/1535370219849592. 

OLIVEIRA MB, VASCONCELLOS JPC, ANANINA G, COSTA VP, MELO MB. Association between IL1A and IL1B polymorphisms and primary open angle glaucoma in a Brazilian population. Exp Biol Med. (Maywood) 2018;243(13):1083-91. doi: 10.1177/1535370218809709. 

MARQUES AM, ANANINA G, COSTA VP, VASCONCELLOS JPC, MELO MB. Estimating the age of the Cys433Arg mutation in the MYOC gene in patients with primary open angle glaucoma. PLoS One. 2018;13(11):e0207409. doi: 10.1371/journal.pone.0207409. 

KHOR CC, DO T, JIA H, NAKANO M, GEORGE R, ABU-AMERO K, DUVESH R, CHEN LJ, LI Z, NONGPIUR ME, PERERA SA, QIAO C, WONG H, SAKAI H, MELO MB et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genet. 2016; 48(5):556-62. doi: 10.1038/ng.3540.

  • Viana JCA, Matiolli CC, Wells Newman D, Vieira GPJ, Duarte TG,  Martins CMM, Gilbault E, Hotta TC, Caldana C,  Vincentz M. The sugar-responsive circadian clock regulator bZIP63 modulates plant growth. New Phytologist (2021) https://doi.org/10.1111/nph.17518
  • Frank A, Matiolli CC, Viana JCA, Hearn TJ, Kusakina j, Belbin FE, Wells Newman D, Yochikawa A, Cano-Ramirez DL, Chembath A, Cragg-Barber K, Haydon M, Hotta T C, Vincentz M, Webb AR A, Dodd N A. Circadian Entrainment in Arabidopsis by the Sugar-Responsive Transcription Factor bZIP63. Current Biology. (2018). doi: 10.1016/j.cub.2018.05.092
  • Vilela MM, Del Bem LE, Van Sluys MA, de Setta N, Kitajima JP, Cruz GM, Sforça DA, de Souza AP, Ferreira PC, Grativol C, Cardoso-Silva CB, Vicentini R, Vincentz M. Analysis of Three Sugarcane Homo/Homeologous Regions Suggests Independent Polyploidization Events of Saccharum officinarum and Saccharum spontaneum. Genome Biol Evol. (2017). doi: 10.1093/gbe/evw293.
  • Thomas Dobrenel, Camila Caldana, Johannes Hanson, Christophe Robaglia, Michel Vincentz, Bruce Veit, and Christian Meyer. TOR Signaling and Nutrient Sensing. (2016) Annu. Rev. Plant Biol. 2016. 67: doi: 10.1146/annurev-arplant-043014-114648.
  • Amanda Bortolini Silveira, Charlotte Trontin, Sandra Cortijo, Joan Barau, Luiz Eduardo Vieira Del Bem, Olivier Loudet, Vincent Colot and Michel Vincentz (2013) Extensive natural epigenetic variation at a de novo originated gene. PLoS Genetics. doi: 10.1371/journal.pgen.1003437.
  • de Setta N, Monteiro-Vitorello CB, Metcalfe CJ, ..27 authors..., Souza GM, Vincentz M, Kitajima JP, Van Sluys MA. Building the sugarcane genome for biotechnology and identifying evolutionary trends. BMC Genomics. (2014) doi: 10.1186/1471-2164-15-540.
  • Duarte GT, Matiolli CC, Pant BD, Schlereth A, Scheible WR, Stitt M, Vicentini R, Vincentz M.(2013) Involvement of microRNA-related regulatory pathways in the glucose-mediated control of Arabidopsis early seedling development. J Exp Bot (2013). 64(14):4301-12. doi: 10.1093/jxb/ert239.
  • Matiolli CC, Tomaz JP, Duarte GT, Prado FM, Del Bem LE, Silveira AB, Gauer L, Corrêa LG, Drumond RD, Viana AJ, Di Mascio P, Meyer C, Vincentz M. (2011) The Arabidopsis bZIP gene AtbZIP63 is a sensitive integrator of transient abscisic acid and glucose signals. Plant Physiol. 157:692-705.
  • Del Bem Luiz EV; Vincentz, M. (2010) Evolution of xyloglucan-related genes in green plants. BMC Evolutionary Biology, 10, 341. doi: 10.1186/1471-2148-10-341.
  • Luiz Gustavo Guedes Corrêa1 LG, Riaño-Pachón DM, Guerra Schrago C, Vicentini dos Santos R, Mueller-Roeber B, Vincentz M. (2008) The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging From Four Founder Genes. PLoS ONE 3(8): e2944. doi: 10.1371/journal.pone.0002944.

•        FABBRI-SCARLLET, H; WERNER, R; SANCHES-GUARAGNA M; ANDRADE JGR; MACIEL-GUERRA, A. T.; HORNIG, N; HIORT, O; GUERRA-JUNIOR, G.; DE MELLO, MP. Can Non-Coding NR5A1 Gene Variants Explain Phenotypes of Disorders of Sex Development? Sexual Development, p. 1-9, 2022. DOI: 10.1159/000524956

•        WATANABE, A*; GUARAGNA, MS*; BELANGERO, VMS; CASIMIRO, FMS; PESQUERO, JB; FELTRAN, LS; PALMA, LM; VARELA, P; NEVES, PDMM; LERARIO, AM; SOUZA, ML; DE MELLO, MP; LUTAIF, AC; FERRARI, CR; SAMPSON, MG; ONUCHIC, LF; NOGUEIRA, PCK. APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses. Pediatric Nephrology , v. 1, p. 1-0, 2021. (*1a autoria compartilhada) DOI: 10.1007/s00467-021-04960-w

•        GUARAGNA, MS.; DE SOUZA, MARCELA L.; LUTAIF, ANNA CRISTINA G.B.; MACIEL-GUERRA, ANDRÉA T.; BELANGERO, V.M.S.; GUERRA-JUNIOR, GIL; MELLO, M.P. Promises and Pitfalls of Whole-Exome Sequencing Exemplified by a Nephrotic Syndrome Family. Mol. Genet Genomics 2020 Jan;295(1):135-142. DOI: 10.1007/s00438-019-01609-0

•        KARLSSON, L.; MICHELATTO, D. P. ; LUSA, A. L. G.; SILVA, CDAM; ÖSTBERG L; PERSSON, B.; GUERRA-JÚNIOR, GIL; LEMOS-MARINI, S. H. V.; BALDAZZI, L; MENABÒ, S; BALSAMO, A.; GREGGIO, N. A.; DE MELLO, M.P.; BARBARO M; LAJIC S. Novel non-classic CYP21A2 variants, including combined alleles, identified in patients with congenital adrenal hyperplasia. Clinical Biochemistry v. 73, p. 50-56, 2019. DOI: 10.1016/j.clinbiochem.2019.07.009

•        FABBRI-SCALLET, HELENA; SOUSA, LIZANDRA MAIA; MACIEL-GUERRA, ANDRÉA TREVAS; GUERRA-JÚNIOR, GIL; DE MELLO, MARICILDA PALANDI. Mutation update for the gene involved in DSD and infertility. Human Mutation 2019; 1-11. DOI: 10.1002/humu.23916

•        FABBRI, H. C. ; DE MELLO, MARICILDA PALANDI ; GUERRA-JÚNIOR, GIL ; MACIEL-GUERRA, ANDRÉA TREVAS ; ANDRADE JGR ; MAIA COSTA DE QUEIROZ, C ; MONLLEO, I. L. ; STRUVE, D ; HIORT, O ; WERNER, R . Functional Characterization of Five NR5A1 Gene Mutations Found in Patients with 46,XY Disorders of Sex Development. HUMAN MUTATION, v. 39, p. 114-123, 2018. DOI: 10.1002/humu.23353

•        GUARAGNA, MS.; ANNA CRISTINA G.B. LUTAIF; CRISTIANE S.C. PIVETA; MARCELA L. SOUZA; SUÉLLEN R. DE SOUZA; TACIANE B. HENRIQUES; ANDRÉA T. MACIEL-GUERRA; VERA M.S. BELANGERO; GIL GUERRA-JUNIOR; Maricilda P. De Mello. NPHS2 mutations account for only 15% of Nephrotic Syndrome cases. BMC Medical Genetics 2015 Sep 29;16:88. DOI: 10.1186/s12881-015-0231-9

  • AJG Simpson, FC Reinach, P Arruda et al (2000) The genome sequence of the plant pathogen Xylella fastidiosa. Nature 406, 151
  • AL Vettore, FR da Silva, EL Kemper, ...P Arruda (2003) Analysis and functional annotation of an expressed sequence tag collection for tropical crop sugarcane. Genome research 13, 2725-2735. https://doi.org/10.1038/35018003.
  • IAP Neshich, E Kiyota, P Arruda (2013) Genome-wide analysis of lysine catabolism in bacteria reveals new connections with osmotic stress resistance. The ISME journal 7, 2400. https://doi.org/10.1038/ismej.2013.123.
  • P Barreto, V Okura, IA Pena, R Maia, IG Maia, P Arruda (2015) Overexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response in Nicotiana tabacum leaves. Journal of Experimental Botany 67, 301-313. https://doi.org/10.1186/1471-2229-14-144
  • E Kiyota, IA Pena, P Arruda (2015) The saccharopine pathway in seed development and stress response of maize. Plant, Cell & Environment 38, 2450-2461.
    https://doi.org/10.1111/pce.12563.
  • RSC De Souza, VK Okura, JSL Armanhi, B Jorrín, N Lozano, MJ Da Silva, M González-Guerrero, LM Araújo, NC Verza, HC Bagheri, J Imperial, P Arruda (2016) Unlocking the bacterial and fungal communities’ assemblages of sugarcane microbiome. Scientific Reports 6, 28774. https://doi.org/10.1038/srep28774.
  • JSL Armanhi, RSC De Souza, LM De Araújo, VK Okura, P Mieczkowski, J Imperial, P Arruda (2016) Multiplex amplicon sequencing for microbe identification in community-based culture collections. Scientific Reports 6, 29543. https://doi.org/10.1038/srep29543.
  • JSL Armanhi, RSC de Souza, NB Damasceno, LM de Araújo, J Imperial, P Arruda (2018) A community-based culture collection for targeting novel plant growth-promoting bacteria from the sugarcane microbiome. Frontiers in Plant Science 8, 2191. https://doi.org/10.3389/fpls.2017.02191.
  • Barreto, Pedro, Charlene Dambire, Gunjan Sharma, Jorge Vicente, Rory Osborne, Juliana Yassitepe, Daniel J. Gibbs, Ivan G. Maia, Michael J. Holdsworth, and Paulo Arruda. 2022. Mitochondrial Retrograde Signaling through UCP1-Mediated Inhibition of the Plant Oxygen-Sensing Pathway. Current Biology 32 (6): 1403-1411.e4. https://doi.org/10.1016/j.cub.2022.01.037.
  • Fanti, R. C., Vasconcelos, S. N. S., Catta-Preta, C. M. C., Sullivan, J. R., Riboldi, G. P., dos Reis, C. v., Ramos, P. Z., Edwards, A. M., Behr, M. A., & Couñago, R. M. (2022). A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.2c00073
  • Lins, É. M., Oliveira, N. C. M., Reis, O., Ferrasa, A., Herai, R., Muotri, A. R., Massirer, K. B., & Bengtson, M. H. (2022). Genome-wide translation control analysis of developing human neurons. Molecular Brain, 15(1), 55. https://doi.org/10.1186/s13041-022-00940-9
  • Wu, Qin, David Y. Nie, Wail Ba-alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, et al. 2022. “PRMT Inhibition Induces a Viral Mimicry Response in Triple-Negative Breast Cancer.” Nature Chemical Biology, May. https://doi.org/10.1038/s41589-022-01024-4.
  • Segretti, Natanael D., Jéssica E. Takarada, Marcos A. Ferreira, André da Silva Santiago, Bruno V.M. Teodoro, Mariana C.F.C.B. Damião, Paulo H. Godoi, et al. 2022. “Discovery of Novel Benzothiophene Derivatives as Potent and Narrow Spectrum Inhibitors of DYRK1A and DYRK1B.” Bioorganic & Medicinal Chemistry Letters 68 (July): 128764. https://doi.org/10.1016/j.bmcl.2022.128764.
  • Papes, Fabio, Antonio P. Camargo, Janaina S. de Souza, Vinicius M. A. Carvalho, Ryan A. Szeto, Erin LaMontagne, José R. Teixeira, et al. 2022. “Transcription Factor 4 Loss-of-Function Is Associated with Deficits in Progenitor Proliferation and Cortical Neuron Content.” Nature Communications 13 (1): 2387. https://doi.org/10.1038/s41467-022-29942-w.
  • Ricardo, Ricardo A., André da Silva Santiago, Martin P. Schwalm, Zexi Hu, Caio v. dos Reis, Jessica E. Takarada, Priscila Mezzomo, et al. 2022. “Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.” Journal of Medicinal Chemistry 65 (4). https://doi.org/10.1021/acs.jmedchem.1c01165.
  • Scott, Fiona, Angela M. Fala, Jessica E. Takarada, Mihaela P. Ficu, Lewis E. Pennicott, Tristan D. Reuillon, Rafael M. Couñago, Katlin B. Massirer, Jonathan M. Elkins, and Simon E. Ward. 2022. “Development of Dihydropyrrolopyridinone-Based PKN2/PRK2 Chemical Tools to Enable Drug Discovery.” Bioorganic and Medicinal Chemistry Letters 60.  https://doi.org/10.1016/j.bmcl.2022.128588.
  • Eduful, Benjamin J., Sean N. O’Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph R. Pilotte, et al. 2021. “Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.” Journal of Medicinal Chemistry 64 (15): 10849–77. https://doi.org/10.1021/acs.jmedchem.0c02274.
  • Ferreira, Tiago R., Rafael M. Couñago, and Nilmar S. Moretti. 2021. “Raising the Bar(-Seq) in Leishmania Genetic Screens.” Trends in Parasitology 37 (5): 367–69. https://doi.org/10.1016/j.pt.2021.03.002.
  • Cabarca, Sindy, Maximilia Frazão de Souza, Andrew Albert de Oliveira, Gabriel S. Vignoli Muniz, M. Teresa Lamy, Caio Vinicius dos Reis, Jessica Takarada, et al. 2021. “Structure of the Mycobacterium Tuberculosis CPknF and Conformational Changes Induced in Forkhead-Associated Regulatory Domains.” Current Research in Structural Biology 3: 165–78. https://doi.org/10.1016/j.crstbi.2021.07.001.

 

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